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ea0019p140 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Heterozygous knockout of the insulin-like growth factor 1 receptor in mice leads to impaired glucose tolerance, enhanced insulin sensitivity and increased endothelial basal nitric oxide production

Abbas A , Imrie H , Viswambharan H , Rajwani A , Kahn M , Cubbon R , Gage M , Wheatcroft S , Grant P , Kearney M

Introduction: Insulin-like growth factor 1 (IGF-1), acting via similar signalling pathways to insulin, enhances glucose uptake and nitric oxide (NO) production. Observational studies suggest a role for (IGF-1) in insulin resistance and cardiovascular disease. To investigate this further we used a murine model with heterozygous knockout of the IGF-1 receptor.Methods: Metabolic tolerance tests were performed in vivo on unanaesthetised mice, heterozy...

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Heterozygous knockout of the insulin-like growth factor 1 receptor in mice leads to impaired glucose tolerance, enhanced insulin sensitivity and increased endothelial basal nitric oxide production

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